Pre-Treatment Healthchecks January 16, 2026

Are You Really Low in Testosterone? The Truth About TRT vs. Clomiphene

Feeling like you’ve lost your edge? Struggling with low energy, a lagging libido, or finding it harder to stay in shape? You’re not alone. In the UK, a significant number of men are silently battling the symptoms of low testosterone. In fact, studies show that between 8-12% of men aged 40-69 in the UK have testosterone deficiency (TD) [1]. That could be nearly 1 million men in the UK who have been diagnosed with low testosterone [2].

But what can you do about it? The internet is awash with information, and it’s easy to get lost in a sea of conflicting advice. Two treatments you may have come across are Testosterone Replacement Therapy (TRT) and Clomiphene. But which one is right for you? And more importantly, how do you even know if you need treatment in the first place?

The Gold Standard: Testosterone Replacement Therapy (TRT)

For men with clinically diagnosed low testosterone, TRT is the gold standard treatment. It works by replenishing your body’s testosterone levels, bringing them back into a healthy, optimal range. The benefits of TRT are well-documented and can be life-changing for many men. These include:

  • Improved Sexual Function: Studies have shown that TRT can significantly improve libido, erectile function, and overall sexual activity [3].
  • Increased Muscle Mass and Strength: TRT can help you build and maintain muscle mass, even as you get older [4].
  • Enhanced Mood and Energy: Many men on TRT report feeling more energetic, motivated, and with an improved sense of well-being [5].
  • Stronger Bones: TRT can increase bone mineral density, reducing the risk of fractures [6].

The Alternative: Clomiphene Citrate

Clomiphene Citrate (often sold as Clomid) is another medication that is sometimes used ‘off-label’ to treat low testosterone. It works differently from TRT. Instead of providing your body with testosterone, it stimulates your body to produce more of its own. While this might sound appealing, the evidence suggests that it’s not as effective as TRT.

One study directly comparing the two treatments found that while both increased testosterone levels, TRT was more effective at raising serum testosterone levels and improving the symptoms of hypogonadism [7]. The same study also found that some men taking Clomiphene experienced a decrease in libido, which is often one of the primary reasons men seek treatment in the first place.

The First Step: Get Tested

Before you even consider any form of treatment, the first and most crucial step is to get your testosterone levels tested. Self-diagnosing based on symptoms alone is not enough. Many other conditions can cause similar symptoms, and it’s essential to get a clear, accurate picture of what’s going on in your body.

A simple blood test is the only way to know for sure if you have low testosterone. It’s a quick and easy process that will give you the answers you need to take control of your health.


About the Author

Dr. Raphael Olaiya is a UK-based General Practitioner and a specialist in Testosterone Replacement Therapy. With years of experience helping men optimise their health, Dr. Olaiya is dedicated to providing safe, effective, and evidence-based care. (GMC No. 7492303)


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References

[1] Awareness and prevalence of the symptoms of testosterone deficiency in men in the United Kingdom: a cross-sectional survey – BMJ Open
[2] Why are we missing the diagnosis of low testosterone in men? – Dr Jeff Foster
[3] Effects of Testosterone Treatment in Older Men – The New England Journal of Medicine
[4] Testosterone and the aging male: to treat or not to treat? – PubMed Central
[5] Testosterone and the aging male: to treat or not to treat? – PubMed Central
[6] Effects of Testosterone and Finasteride on Bone Mineral Density and Body Composition in Elderly Men with Low-Normal Testosterone Levels – The Journal of Clinical Endocrinology & Metabolism
[7] Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men – Indian Journal of Urology

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